|
姓名：张前 |
职称/职务：副教授 |
电话： |
传真： |
电子信箱：zhangqian154@snnu.edu.cn |
研究方向：1.中药物质基础；2.针对中枢神经系统疾病的药物筛选及机制研究 |
办公地点： |
一、个人简介
张前，博士，硕士研究生导师。本科及硕士就读于西北大学js33333金沙线路检测，博士毕业于上海中医药大学中药研究所。2013-2020年任职于西安交通大学附属红会医院转化医学中心，2021年至今任职于js33333金沙线路检测。
主持国家自然科学基金1项，省自然科学基金2项，省中医药管理局项目1项，中央高校科研项目1项，参与多项国家级、省级课题。发表第一/通讯作者SCI论文十余篇。Neural Regeneration Research, Phytomedicine, Phytotherapy Research等杂志审稿人。
二、主要研究领域及兴趣
1.中药物质基础；
2.针对中枢神经系统疾病的药物筛选及机制研究。
三、承担的科研项目
1.陕西省自然科学基金重点项目，2022JZ-46，针对脊髓损伤的黄芩“清热燥湿”效应成分辨识及作用机制研究，2022.1.1-2024.12.31，主持。
2.中央高校基本科研业务费一般项目，GK202103079，黄芩苷通过IKK/NF-κB通路干预脊髓损伤后炎症及凋亡的机制研究，2021.1.1-2022.12.31，主持。
3陕西省自然科学基金面上项目，2017JM8058，丹参-黄芩对大鼠脊髓损伤后血-脊髓屏障的保护作用及其机制研究，2017.1.1-2018.12.31，主持。
4.陕西省中医药管理局项目，15-ZY038，丹参、黄芩联合治疗大鼠脊髓损伤的配伍规律及合理性研究，2016.1.1-2017.12.31，主持。
5.国家自然科学基金青年项目，81403278，丹参-黄芩干预大鼠脊髓损伤后早期炎症反应的作用机制及物质基础研究，2015.1.1-2017.12.31，主持。
五、代表性论文
1. Rui Zhao#, Xue Wu#, Xue-Yuan Bi, Hao Yang,Qian Zhang*. Baicalin attenuates blood-spinal cord barrier disruption and apoptosis through PI3K/Akt signaling pathway after spinal cord injury. Neural Regeneration Research, 2022, 17(5): 1080-1087.
2. Xue Wu, Yaping Yan,Qian Zhang*. Neuroinflammation and modulation role of natural products after spinal cord injury, Journal of Inflammation Research, 2021, 14: 5713-5737.
3. Rui Zhao, Xifang Liu, Lixin Zhang, Hao Yang,Qian Zhang*. Current Progress of Research on Neurodegenerative Diseases of Salvianolic acid B. Oxidative Medicine and Cellular Longevity. 2019, doi.org/10.1155/2019/3281260.
4.Qian Zhang*, Xifang Liu, Liang Yan, Rui Zhao, Jing An, Ciucui Liu, Hao Yang. Danshen extract (Salvia miltiorrhiza Bunge) attenuate spinal cord injury in a rat model: a metabolomic approach for the mechanism study. Phytomedicine. 2019, 62, 152966.
5. Lixin Zhang, Xifang Liu, Hao Yang, Rui Zhao, Cuicui Liu, Rui Zhang,Qian Zhang*. Comparative pharmacokinetic study on phenolic acids and flavonoids in spinal cord injury rats plasma by UPLC-MS/MS after single and combined oral administration of danshen and huangqin extract. Journal of Pharmaceutical and Biomedical Analysis. 2019, 172: 103-112.
6.Qian Zhang*, Li-Xin Zhang, Jing An, Liang Yan, Cui-Cui Liu, Jing-Jing Zhao, Hao Yang*. Huangqin flavonoid extraction for spinal cord injury in a rat model. Neural Regeneration Research. 2018, 13(12): 2200-2208.
7.Qian Zhang*, Hao Yang, Jing An, Rui Zhang, Bo Chen, Ding-Jun Hao. Therapeutic Effects of Traditional Chinese Medicine on Spinal Cord Injury: A Promising Supplementary Treatment in Future. Evidence-Based Complementary and Alternative Medicine. 2016; 2016:8958721. doi: 10.1155/2016/8958721. Epub 2016 Mar 28.
8.Qian Zhang, Yueming Ma, Zhengtao Wang, Changhong Wang*. Pharmacokinetics difference of multiple active constituents from decoction and maceration of Fuzi Xiexin Tang after oral administration in rat by UPLC–MS/MS. Journal of Pharmaceutical and Biomedical Analysis. 2014, 92: 35-46.
9.Qian Zhang, Changhong Wang, Yueming Ma, Zhengtao Wang*. Difference in pharmacokinetics and anti-inflammatory effect between decoction and maceration of Sanhuang Xiexin Tang in rats and mice. Planta Medica. 2013, 79(17): 1666-1673.
10.Qian Zhang, Changhong Wang, Yueming Ma, Enyuan Zhu, Zhengtao Wang*. UPLC-ESI/MS determination of 17 active constituents in two categorized formulas of Traditional Chinese Medicine, Sanhuang Xiexin Tang and Fuzi Xiexin Tang: Application in comparing with the differentials in decoctions and macerations. Biomedical Chromatography. 2013, 27(8): 1079-1088.
