闫亚平

一、个人简介

闫亚平博士，教授，博士生导师。js33333金沙线路检测院长，兼任药用资源与天然药物化学教育部重点实验室主任，教育部高等院校药学类教学指导委员会委员，陕西省高等学校教学指导委员会药学类副主任委员。主要从事神经免疫、神经感染和神经炎症性疾病的辅助诊断、发病机制与实验治疗研究，致力于该类疾病新的床旁辅助诊断方法的建立、治疗新靶点的发现以及免疫炎症在疾病发生发展中的作用等。先后主持国家自然科学基金项目5项，国家重点研发计划项目课题1项，参与973计划项目1项；在Molecular Therapy、Journal of Immunology、Brain、behavior and Immunity、Neurology N2等杂志上发表80余篇学术论文，论文被引3100余次；申请国家发明专利70项，其中已获授权27项；获省部级科学技术奖励二等奖2项。

二、主要研究领域及兴趣

1.视神经脊髓炎谱系疾病的发病机制与实验治疗；

2.脱髓鞘疾病髓鞘损伤及修复的机制；

3.神经免疫病辅助诊断试剂盒的开发。

三、在研的科研项目

1.主持陕西省自然科学基础研究计划项目-杰出青年基金项目，2023-JC-JQ-64，神经免疫病的辅助诊断及实验治疗，2023/01-2025/12；

2.主持国家自然科学基金面上项目，82071348，SPARC抑制VEGF/VEGFR信号通路调控星形胶质细胞CD59表达参与NMO中枢特异性病灶形成的机制研究，2021/01-2024/12；

3.主持陕西省重点产业创新链（群）项目，2020ZDCYL-SF-009，神经免疫病体外诊断试剂盒的开发与产业化，2020/07-2023/06。

四、代表性论文（#第一作者，*通讯作者）

1.Yang Y*, Yu J, Huo J,Yan Y*. Sesamolin attenuates kidney injury, intestinal barrier dysfunction, and gut microbiota imbalance in high-fat and digh-fructose diet-fed mice,J. Agric. Food. Chem., 2023, 71, 3, 1562-1576.

2.Fu Y*, Zhao W, Lin K, Lv A, Tian L, Wang Z, Li S,Yan Y*. USPIO-SWI shows fingolimod enhanced alteplase action on angiographic reperfusion in eMCAO rats,J. Magn. Reson. Imaging, 2022, 55, 1095-1106.

3.Gong Y, Liu Y, Ding X, Fu Y, Cui L*,Yan Y*. Tanshinone IIA ameliorates CNS autoimmunity by promoting the differentiation of regulatory T cells,Neurotherapeutics, 2020, 17 (2): 690-703.

4.Gong Y#, Zhang Y#, Wang Z, Song H, Liu Y, Lv A, Tian L, Zhu W, Fu Y, Ding X, Cui L*,Yan Y*. Tanshinone IIA alleviates brain damage in a mouse model of neuromyelitis optica spectrum disorder by inducing neutrophil apoptosis,J Neuroinflammation, 2020, 17 (1): 198.

5.Zhu W, Wang Z, Hu S, Gong Y, Liu Y, Song H, Ding X, Fu Y,Yan Y*. Human C5-specific single-chain variable fragment ameliorates brain injury in a model of NMOSD.Neurol Neuroimmunol Neuroinflamm, 2019, 6 (3): e561.

6.Wang Z, Guo W, Liu Y, Gong Y, Ding X, Shi K, Thome R, Zhang G, Shi F,Yan Y*. Low expression of complement inhibitory protein CD59 contributes to humoral autoimmunity against astrocytes.Brain Behav Immun. 2017, 65:173-182.

7.Shi K, Wang Z, Liu Y, Gong Y, Fu Y, Hao JW, Shi F,Yan Y*. CFHR1-Modified Neural Stem Cells Ameliorated Brain Injury in a Mouse Model of Neuromyelitis Optica Spectrum Disorders.J Immunol, 2016, 197(9):3471-3480.

8.Zhang C, Gong Y, Zhu W, Qi Y, Yang C, Fu Y, Chang G, Li Y, Shi S, Wood K, Ladha S, Shi F, Liu Q,Yan Y*. Augmentation of circulating follicular helper T cells and their impact on autoreactive B cells in Myashenia Gravis.J Immunol, 2016, 197: 2610-2617.

9.Yan Y*, Li Y, Fu Y, Yang L, Su L, Shi K, Li M, Liu Q, Borazanci A, Liu Y, He Y, Bennett JL, Vollmer TL, Shi FD*. Autoantibody to MOG suggests two distinct clinical subtypes of NMOSD.Sci China Life Sci, 2016, 59(12): 1270-1281.

10.Li Y, Zhang F, Qi Y, Chang G, Fu Y, Su L, Shen Y, Sun N, Borazanci A, Yang C, Shi FD,Yan Y*. Association of circulating follicular helper T cells with disease course of NMO spectrum disorders.J Neuroimmunol, 2015, 278: 239-246.