田英芳

一、个人简介

田英芳，女，汉，1972年1月出生。js33333金沙线路检测教授。2006年毕业于西安交通大学医学院，获博士学位。2007年12月至2011年8月在美国加州大学戴维斯分校神经发育疾病研究所做博士后研究。1998年至2008年历任西安交通大学医学院助教，讲师，副教授。

二、主要研究领域及兴趣

近年来，主要从事神经系统疾病的分子和神经机制研究。利用丙戊酸诱导的孤独症模型开展了环境因素诱导的孤独症的神经机制研究。在Stroke，J Cereb Blood Flow Metab等国际期刊杂志上以第一/通讯发表文章20余篇。主持国家自然科学基金面上项目2项。

三、承担的科研项目

1.国家自然科学基金项目，丙戊酸诱导的小鼠孤独症样行为的纹状体神经可塑性及机制研究， 2020.01-2023.12，81971285。

2.国家自然科学基金项目，PGRN对脑缺血后的神经再生和神经保护作用及机制研究，2014.01-2017.12，31371501。

四、出版的著作

1. 《神经细胞生物学》，2019，西安交通大学出版社，副主编。

2. 《生物化学简明教程》，2021，高等教育出版社，参编。

3. 《免疫学原理与技术》，2016，高等教育出版社，参编。

五、代表性论文

1.Sun S, Zhou J, Li Z, Wu Y, Wang H, Zheng Q, Adu-Nti F, Fan J, Tian Y*. Progranulin promotes hippocampal neurogenesis and alleviates anxiety-like behavior and cognitive impairment in adult mice subjected to cerebral ischemia. CNS Neurosci Ther. 2 2022 May;28(5):775-787. (SCI, 2区)

2.Diao Z, Yao L, Cheng Q, Wu M, Di Y, Qian Z, Wei C, Liu Y, Tian Y*, Ren W*. Involvement of Midbrain Dopamine Neuron Activity in Negative Reinforcement Learning in Mice. Mol Neurobiol. 2021 Nov;58(11):5667-5681 (SCI, 2区)

3.Diao Z, Di Y, Wu M, Zhai C, Kang M, Li Y, Liu Y, Wei C, Zheng Q, Han J, Liu Z, Tian Y*, Ren W*. Single Exposure to Cocaine Impairs Reinforcement Learning by Potentiating the Activity of Neurons in the Direct Striatal Pathway in Mice. Neurosci Bull. 2021 Aug;37(8):1119-1134. (SCI, 2区)

4.Di Y, Li Z, Li J, Cheng Q, Zheng Q, Zhai C, Kang M, Wei C, Lan J, Fan J, Ren W*, Tian Y*. Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid. Food Funct. 2021 May 21;12(10): 4544-4555. (SCI, 2区)

5.Liu Y, Ren J, Kang M, Zhai C, Cheng Q, Li J, Wu Y, Ruan X, Zhou J, Fan J*, Tian Y*. Progranulin promotes functional recovery and neurogenesis in the subventricular zone of adult mice after cerebral ischemia. Brain Res. 2021 Apr 15; 1757:147312. (SCI, 3区)

6.Wu M, Di Y, Diao Z, Yao L, Qian Z, Wei C, Zheng Q, Liu Y, Han J, Liu Z, Fan J, Tian Y, Ren W. Abnormal reinforcement learning in a mice model of autism induced by prenatal exposure to valproic acid. Behav Brain Res. 2020 Oct 1;395:112836. (SCI, 3区)

7.吴美霖，田英芳(*)，任维.丙戊酸诱导的孤独症模型脑结构功能改变及神经环路研究展望.生命科学，2020, 32(1): 77-82.

8.Tian Y(#*), Di Y, Zhang J, Chen X, Feng T, Adu-Nti F, Shi M, Fan J, Zhang J, Zhang P, Liu Y. Angiogenic gene profiles in Laser-Microdissected microvessels and neurons from ischemic penumbra of rat brain. J Mol Neurosci. 2019, 67(4):643-653. (SCI, 3区)

9.Zhang R, Zhou J, Ren J; Sun S, Di Y, Wang H, An X, Zhang K; Zhang J, Qian Z, Shi M, Qiao Y, Ren W, Tian, Y (*), Transcriptional and splicing dysregulation in the prefrontal cortex in valproic acid rat model of autism. Reprod Toxicol., 2018.2.7, 77: 53~61. (SCI, 3区)

10.Zhou J, Zhang X, Ren J, Wang P, Zhang J, Wei Z, Tian Y. Validation of reference genes for quantitative real-time PCR in valproic acid rat models of autism. Mol Biol Rep. 2016，43(8):837-47. (医学4区)

11.Tian Y*, Stamova BS, Jickling GC, Xu H, Liu DZ, Ander BP, Bushnell C, Zhan X, Turner R, Davis RR, Verro P, C. Pevec WC, Hedayati N3, Dawson DL, Khoury J, Jauch EC, Pancioli A, Broderick JP, and Sharp FR. Effects of gender on gene expression in the blood of ischemic stroke patients, J Cereb Blood Flow Metab. 2012 May;32(5):780-91. (医学2区)

12.Stamova BS, Tian Y(Co-first author), Jickling GC, Xu H, Liu DZ, Ander BP, Bushnell C, Zhan X, Turner R, Davis RR, Verro P, C. Pevec WC, Hedayati N, Dawson DL, Khoury J, Jauch EC, Pancioli A, Broderick JP, and Sharp FR. The X-chromosome has a different pattern of gene expression in woman compared to men with ischemic stroke, Stroke. 2012, 43(2): 326-34. (医学1区)

13.Tian Y*, Liao IH, Zhan X, Gunther JR, Ander BP, Liu D, Lit L, Jickling GC, Corbett BA, Bos-Veneman NG, Hoekstra PJ, Sharp FR.Exon expression and alternatively spliced genes in Tourette Syndrome. Am J Med Genet B Neuropsychiatr Genet. 2011, 156(1):72-8. (医学2区)

14.Tian Y*, Green PG, Stamova B, Hertz-Picciotto I, Pessah IN, Hansen R, Yang X, Gregg JP, Ashwood P, Jickling G, Van de Water J, Sharp FR.Correlations of gene expression with blood lead levels in children with autism compared to typically developing controls. Neurotox Res. 2011, 19(1):1-13. (医学2区)

六、授权专利

1.田英芳，刘颖勋，刁志君，任维。一种单细胞多巴胺受体亚型mRNA表达的巢式PCR检测方法。专利号：ZL 2018 1 0957449.5，专利申请国：中国。